Carsten Speckmann Selected Research

Disease Progression

9/2020	Long-term robustness of a T-cell system emerging from somatic rescue of a genetic block in T-cell development.
3/2010	Chronic inflammatory bowel disease as key manifestation of atypical ARTEMIS deficiency.

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Carsten Speckmann Research Topics

Disease

9	Infections 10/2022 - 03/2010
5	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 01/2022 - 07/2006
4	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2022 - 06/2013
4	Autoimmune Lymphoproliferative Syndrome 01/2017 - 12/2013
3	2 X-Linked Lymphoproliferative Syndrome 01/2022 - 07/2015
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 12/2010
3	Lymphopenia (Lymphocytopenia) 01/2017 - 10/2011
3	Severe combined immunodeficiency due to adenosine deaminase deficiency 06/2013 - 10/2011
2	Colitis 10/2022 - 03/2016
2	Measles 01/2022 - 01/2021
2	Mumps 01/2022 - 01/2021
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022 - 03/2010
2	Cytopenia 04/2021 - 12/2013
2	Chronic Granulomatous Disease 01/2021 - 01/2019
2	Disease Progression 09/2020 - 03/2010
2	Bacterial Infections (Bacterial Infection) 01/2019 - 07/2006
2	X-Linked Combined Immunodeficiency Diseases (X Linked Severe Combined Immunodeficiency) 10/2014 - 11/2008
1	Bronchiectasis 10/2022
1	Lung Diseases (Lung Disease) 10/2022
1	Primary Immunodeficiency Diseases 10/2022
1	Neoplasms (Cancer) 10/2022
1	Immune System Diseases (Immune Disorders) 01/2022
1	Activated PI3K-delta Syndrome 01/2022
1	Chickenpox 01/2022
1	Granuloma 01/2022
1	chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature 10/2021
1	Thrombocytopenia (Thrombopenia) 04/2021
1	Hemolytic Anemia 04/2021
1	Hepatitis C 01/2021
1	Rubella (German Measles) 01/2021
1	Hypertriglyceridemia 09/2020
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 09/2020
1	Prolidase Deficiency 01/2020
1	Neuroinflammatory Diseases 01/2020
1	Pancytopenia 01/2020
1	Respiratory Insufficiency (Respiratory Failure) 01/2020
1	Fever (Fevers) 01/2020
1	Vasculitis (Vasculitides) 01/2019
1	Rare Diseases (Rare Disease) 01/2018
1	Hearing Loss (Hearing Impairment) 11/2017
1	Graft vs Host Disease (Graft-Versus-Host Disease) 04/2017
1	Type 1 Hyper-IgM Immunodeficiency Syndrome 04/2017
1	Cytomegalovirus Infections (Inclusion Disease) 01/2017
1	Autoimmune Pancreatitis 01/2017
1	IgG Deficiency 01/2017
1	Hypergammaglobulinemia (Hyperimmunoglobulinemia) 01/2017
1	Exfoliative Dermatitis (Erythroderma) 10/2015
1	Hereditary Folate Malabsorption 06/2015
1	Neutropenia 07/2014
1	Purine Nucleoside Phosphorylase Deficiency 07/2014

Drug/Important Bio-Agent (IBA)

3	VaccinesIBA 01/2022 - 12/2015
2	Proteins (Proteins, Gene)FDA Link 04/2021 - 11/2017
2	Rituximab (Mabthera)FDA Link 04/2021 - 10/2016
2	CD40 Ligand (CD40L)IBA 04/2021 - 01/2019
2	Sirolimus (Rapamycin)FDA Link 04/2021 - 01/2017
2	Immunoglobulin M (IgM)IBA 01/2019 - 01/2017
2	Antiviral Agents (Antivirals)IBA 01/2017 - 02/2012
2	Biomarkers (Surrogate Marker)IBA 01/2017 - 12/2013
2	2,6-dinitrotoluene (DNT)IBA 01/2016 - 08/2014
2	Immunoglobulin E (IgE)IBA 10/2015 - 10/2011
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 08/2014 - 06/2013
2	EnzymesIBA 07/2014 - 10/2012
2	Adenosine DeaminaseIBA 06/2013 - 10/2012
1	Attenuated VaccinesIBA 01/2022
1	Rubella VaccineIBA 01/2022
1	InflammasomesIBA 01/2022
1	Intravenous Immunoglobulins (IVIG)FDA Link 04/2021
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 04/2021
1	daratumumabIBA 04/2021
1	Adrenal Cortex Hormones (Corticosteroids)IBA 04/2021
1	eltrombopag FDA Link 04/2021
1	Prednisolone (Predate)FDA LinkGeneric 04/2021
1	LipopolysaccharidesIBA 04/2021
1	Interleukin-27 (Interleukin 27)IBA 01/2021
1	sofosbuvir drug combination ledipasvirIBA 01/2021
1	Pharmaceutical PreparationsIBA 09/2020
1	GlucocorticoidsIBA 09/2020
1	LipidsIBA 09/2020
1	Immunoglobulins (Immunoglobulin)IBA 09/2020
1	pegaspargase (Oncaspar)FDA Link 09/2020
1	AnticoagulantsIBA 01/2020
1	Interleukin-18 (Interleukin 18)IBA 01/2019
1	NADP (NADPH)IBA 01/2019
1	Immunoglobulin A (IgA)IBA 01/2019
1	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2019
1	5' Untranslated Regions (5' UTR)IBA 01/2018
1	Immunoglobulin G (IgG)IBA 01/2017
1	Azathioprine (Imuran)FDA LinkGeneric 10/2016
1	Nonsense Codon (Nonsense Mutation)IBA 07/2015
1	Proton-Coupled Folate TransporterIBA 06/2015
1	CytokinesIBA 10/2014
1	Interleukin-2 Receptors (IL 2 Receptor)IBA 10/2014

Therapy/Procedure

10	Hematopoietic Stem Cell Transplantation 01/2022 - 07/2006
6	Therapeutics 04/2021 - 07/2006
4	Cell Transplantation 01/2022 - 10/2012
3	Stem Cell Transplantation 01/2021 - 03/2010
2	Transplantation 04/2017 - 03/2016
1	Splenectomy 10/2022
1	Blood Component Removal (Apheresis) 09/2020
1	Extracorporeal Membrane Oxygenation 01/2020